Official websites use. Share sensitive information only on official, secure websites. LSDV does not complete its replication cycle in non-ruminant hosts. This regimen also induced a 1. LSDV was demonstrated to be non-pathogenic in immunocompromised mice. The rLSDV-grttn vaccine was immunogenic in mice particularly in prime-boost regimens.
This trial is the only one to demonstrate some protection from HIV infection [ 2 ]. The other two efficacy trials tested homologous prime-boost regimens gp protein [ 3 ] or a combination of adenovirus based vaccines [ 4 ] and showed no protection from HIV infection. These results confirm that HIV candidate vaccines induce more effective immune responses when used in heterologous prime - boost regimens [ 5 , 6 ].
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Homologous prime-boost vaccination regimens are not as effective in inducing strong immune responses partially due to the blunting effect of anti-vector immunity [ 7 , 8 ].
There is some evidence that pre-immunity to the poxvirus vectors results in lower immune responses. Another study with an HIV vaccine with three DNA vaccine primes and an MVA boost demonstrated that while pre-immunity to VV did not abolish the immune response the magnitude of response was lower than when there was no pre-immunity [ 9 ].
Prime-boost vaccination regimens are also favourable as the memory T cells induced by the secondary vaccination retain the effector memory TEM phenotype longer than T cells generated by priming alone [ 11 ].
