Official websites use. Share sensitive information only on official, secure websites. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author s and source are credited. On a per-lesion basis characteristic PET values were tested as cut-offs. All other tested cut-offs were inferior to the SUV max.
Low dose and lack of iodine contrast in the CT component do not impact the accuracy. Colorectal cancer is a leading cause of morbidity and mortality worldwide [ 1 ], despite being curable if detected early and even preventable if dysplastic adenomas as their precursors are eliminated [ 2 — 4 ]. Thus, colorectal screening has been shown to reduce the risk of dying from colorectal cancer.
Consequently, colonoscopy was recommended early on for colorectal screening [ 5 ]. In computed tomography colonography CTC [ 6 ] and in magnetic resonance colonography MRC [ 7 ] were also proposed for colorectal screening.
They have several advantages: minimally invasive, fast, detect extracolonic disease, and allow computer-aided detection. CT colonography has been recommended in the colorectal screening guidelines since [ 8 ]. FDG is a glucose analogue that is taken up by cellular glucose transport mechanisms.
In the cell, FDG is phosphorylated by hexokinase. Thus, FDG accumulation mostly correlates with the grading and the degree of malignancy. Because only 2. Through neglecting PET-negative lesions unnecessary colonoscopies and polypectomies might possibly be prevented. PET images were iteratively reconstructed with 5-mm-thick slices.
