Official websites use. Share sensitive information only on official, secure websites. Antonis C. Licensed under the Creative Commons Attribution 4. To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants PVs in BRCA1 and BRCA2 for effective cancer risk management.
Associations with colorectal and gallbladder cancers were also suggested. The stomach cancer RR was higher for females than males 6. The absolute risks to age 80 years ranged from 0. Precise risk estimates are required to inform effective cancer risk management. No associations were found with risks of other cancers. The cumulative risks to age 80 years ranged from 0. The findings provide age-specific cancer risk estimates and will allow for improved cancer risk assessment of male and female carriers.
All participants provided written informed consent and participated in studies at the host institutions under ethically approved protocols.
Complex segregation analysis, 25 which considered the observed phenotype and observed or inferred genotype information of all family members, was used to estimate relative risks RRs for 22 first primary cancer sites, excluding female breast and ovarian cancers Table 1.
This involved comparing the observed cancer incidences for carriers with the age-, country- and birth cohort-specific population incidences Cancer Incidence in Five Continents 26 ; thus, the estimated RRs were equivalent to standardized incidence ratios.
