The purpose of the present study was to gain new insights into the interactions between STN-DBS and cortical network activity. We therefore combined high-resolution functional near-infrared spectroscopy with low-resolution electroencephalography in seven Parkinsonian patients on STN-DBS, and measured cortical haemodynamic changes at rest and during hand movement in the presence and absence of stimulation the ON-stim and OFF-stim conditions, respectively in the off-drug condition.
The relative changes in oxyhaemoglobin [HbO], deoxyhaemoglobin [HbR], and total haemoglobin [HbT] levels were analyzed continuously. Citation: Mahmoudzadeh M, Wallois F, Tir M, Krystkowiak P, Lefranc M Cortical hemodynamic mapping of subthalamic nucleus deep brain stimulation in Parkinsonian patients, using high-density functional near-infrared spectroscopy.
This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability: Data cannot be shared publicly because of ethical restrictions and data protection laws. Data are available to researchers who meet the criteria for access to confidential data from the institutional ethics committee of University hospital of Amiens contact via corresponding author or Yoanna Josse: Yoanna Josse yoanna. Competing interests: The authors have declared that no competing interests exist. Most treated patients experience a dramatic overall reduction in motor symptoms and an improvement in quality of life [ 5 , 6 ].
However, despite rigorous preoperative selection and optimized positioning of the DBS lead inside the STN, some patients fail to benefit from this technique [ 7 — 12 ]. This mechanistic knowledge would help to elucidate STN-DBS possible implication in the clinical effects observed after surgery, individually assess postoperative outcomes, and thus improve the management of stimulation-refractory patients.
