Official websites use. Share sensitive information only on official, secure websites. E-mail: kellygiudici gmail. There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation.
Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration.
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Peripheral and cerebral inflammatory processes affect cognitive function through several potential mechanisms, in a complex cross-talk between microglia brain-resident macrophages , systemic immune cells, and circulating mediators such as cytokines and chemokines 4β6 , which becomes more strongly triggered with the age-related immune dysfunction immunosenescence 6.
Among the growing number of inflammation-related molecules, tumor necrosis factor receptor 1 TNFR-1 , monocyte chemoattractant protein 1 MCP-1 , interleukin 6 IL-6 , and growth differentiation factor 15 GDF emerge as biomarkers potentially related to neurodegeneration 4 , 7β9. Moreover, adequate intake of the aforementioned nutrients also favors the fight against inflammation 13β In a scenario in which available evidence still does not allow reaching a consensus on blood biomarkers profiles for the early prediction of neurodegeneration and cognitive impairment 16β19 , further efforts are needed to help define the best care protocols.
Briefly, interventions were not able to reduce cognitive decline Participants were observationally followed for 2 additional years after the end of the 3-year interventional phase. Inclusion started in May and ended in February ; follow-up ended in April Detailed information about the MAPT protocol has been published elsewhere These biomarkers were not measured at baseline due to unavailability of plasma samples.
