Moore, 62, picked up the leading actress award for body horror The Substance and Chalamet, 29, secured the leading actor prize for Bob Dylan biopic A Complete Unknown at the 31st annual awards ceremony held at the Shrine Auditorium Expo Hall in Los Angeles. During her acceptance speech Moore, who plays a TV fitness instructor who turns to a miracle drug after being sacked from her job, reflected on her membership of the acting organisation from the age of 15, saying it "changed my life because it gave me meaning".
She added: "It gave me purpose. It gave direction. I was a kid on my own who had no blueprint for life. I knew nothing about acting, but I watched and I listened and I learned from all of you.
I am so grateful that I have continued over these so many years to be able to try and sometimes succeed and sometimes fail, but to be able to keep going.
The outstanding performance by a cast in a motion picture went to Conclave, fronted by British actor Ralph Fiennes - who plays a cardinal overseeing the election of a new pope who is beset by scheming fellow men of god, including Sergio Castellitto and John Lithgow's characters.
They all took to the stage at the event along with Italian actress Isabella Rossellini, who has a standout role as a fierce nun in the Edward Berger-directed Vatican drama. Earlier in the evening, introducing the film, Rossellini said "we would like to wish Pope Francis a quick recovery" following news that the pontiff remained in a "critical condition" with early kidney failure on Sunday.
