Official websites use. Share sensitive information only on official, secure websites. Corresponding author. The lack of treatment options for congenital 0. Over two decades of dedicated research have led to breakthroughs in the treatment of congenital and acquired tooth loss.
We revealed that by inactivating USAG-1 , congenital tooth agenesis can be successfully ameliorated during early tooth development and that the inactivation promotes late-stage tooth morphogenesis in double knockout mice.
Furthermore, Anti- USAG-1 antibody treatment in mice is effective in tooth regeneration and can be a breakthrough in treating tooth anomalies in humans.
With approximately 0. Understanding the role of pathogenic USAG-1 variants, their interacting gene partners, and their protein functions will help develop critical biomarkers. Advances in next-generation sequencing, mass spectrometry, and imaging technologies will assist in developing companion and predictive biomarkers to help identify patients who will benefit from tooth regeneration. Loss of teeth due to congenital or acquired diseases or accidents is a common health condition in almost all age groups, especially in the aging populations.
Current approaches to treating tooth loss include prostheses, transplantations, and dental implants. Therefore, to address the unmet needs of oral care, new strategies and therapeutic alternatives, such as tooth regeneration, are required for patients to regain normal food intake and lifestyle. However, this issue remains a challenge for dental researchers and the dental industry. Over the past decade, the integration of health and life science fundamentals with advanced chemistry and engineering has provided alternatives and advanced therapeutics for tooth regeneration [ 1 ].
