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Eating disorders EDs -including anorexia nervosa AN , bulimia nervosa, and binge-eating disorder-are clinically distinct, but exhibit high symptom overlap and comorbidity. Genomic analyses to date have only examined AN. We conducted the first genome-wide association meta-analysis of binge-eating behaviour BE; 39, cases, 1,, controls, all from European genetic ancestries , alongside new analyses of AN 24, cases, 1,, controls, all from European genetic ancestries and its subtypes. We implicated six genomic loci associated with BE, including known associations with higher body mass index BMI and impulse-control behaviours.
BE and AN exhibit genetic similarity, including positive genetic correlation with psychiatric disorders, and genetic dissimilarity, including opposing genetic correlations with anthropometric traits. Genomic structural equation modelling analyses indicate that most genetic signal in EDs is independent of BMI.
We have extended ED genomics beyond AN; work is underway to diversify further, incorporating multiple diagnoses and global genetic ancestries. No authors nor their institutions at any time received payment or services from a third party for any aspect of the submitted work including but not limited to grants, data monitoring board, study design, manuscript preparation, statistical analysis, etc.
Additional Danish cases: All participants provided written informed consent before participating in the study. All participants were broadly consented for research. Informed consent for the use of data collected via questionnaires and clinics was obtained from participants following the recommendations of the ALSPAC Ethics and Law Committee at the time.
The main caregiver initially provided consent for child participation, and from the age of 16 years, the offspring themselves have provided informed written consent. Recruitment protocols followed the biobank protocols approved by Valvira. In addition, informed consent has been obtained from the study participants.