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While her mother moved to the United States with her little brother, Carina stayed in Italy with their father. After he and Sam Bello broke up the first time, Andrew spent three weeks on her couch.
At some point prior to moving to the US, Carina was sexually assaulted. When Carina learned that her brother was working for a female Chief of Surgery, she came to Seattle to meet with Miranda Bailey about doing her research at Grey Sloan Memorial.
She talked with Bailey and got permission to use the hospital's MRI to take pictures of women's brains before, during, and after orgasm. Amelia offered to participate in the study and her MRI showed a brain tumor. When Carina learned that Arizona had a patient who was having a difficult, slow labor and couldn't use any medical means to hasten her labor, she suggested clitoral stimulation to provide natural pain relief and speed up her labor. Despite her initial reservations, Arizona suggested it to her patient and with her husband's assistance, labor quickly progressed.
While watching Amelia's surgery with Arizona, Carina was delighted that Amelia's tumor had been discovered because of masturbation, saying God works in mysterious ways.
