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Immune checkpoint inhibitors ICIs are the standard of care for the treatment of several cancers. While these immunotherapies have improved patient outcomes in many clinical settings, they bring accompanying risks of toxicity, specifically immune-related adverse events irAEs.
There is a need for clear, effective guidelines for the management of irAEs during ICI treatment, motivating the Society for Immunotherapy of Cancer SITC to convene an expert panel to develop a clinical practice guideline.
The panel discussed the recognition and management of single and combination ICI irAEs and ultimately developed evidence- and consensus-based recommendations to assist medical professionals in clinical decision-making and to improve outcomes for patients. You will be able to get a quick price and instant permission to reuse the content in many different ways. The introduction of new cancer immunotherapies for the treatment of metastatic cancer and for the adjuvant therapy for high-risk primary disease has enabled long-term, potentially curative responses in subsets of populations of patients with cancer.
Immune checkpoint inhibitors ICIs are antibodies designed to block key regulatory signals that dampen immune responses, counteracting immune suppression in the tumor microenvironment and thus enabling tumor-reactive T cells to mount an effective anticancer response.
The use of ICIs as adjuvant therapy has been approved for high-risk melanoma and esophageal and gastroesophageal junction GEJ cancers, and studies of peri-operative checkpoint blockade including in the neoadjuvant setting are ongoing for a wide variety of other cancers. Because ICIs are used across the spectrum of disease from early to late stage, the risks of treatment including the potential for long-lasting side effects should be weighed against the goals of therapy.