Official websites use. Share sensitive information only on official, secure websites. Corresponding author. E-mail: kimberlp ucla. Paraquat dichloride is currently among the most widely used commercial herbicides in the USA.
Based on PD patients and community controls, we assessed associations between ambient paraquat dichloride exposure and PD. We estimated residential and workplace proximity to commercial agricultural applications in three California counties since using the CA pesticide use reporting PUR data and land use maps.
We evaluated any, duration and average intensity [pounds 0. Ambient paraquat exposure assessed at both residence and workplace was associated with PD, based on several different exposure measures. The PD patients both lived and worked near agricultural facilities applying greater amounts of the herbicide than community controls. Paraquat dichloride, commonly known as paraquat, is currently one of the most widely used commercial herbicides in the USA.
A recent report from the Agricultural Health Study AHS suggested no association, 8 contradicting positive associations previously reported in a nested case-control study from the same cohort. Experimental research has shown that paraquat crosses the blood-brain barrier 10 , 11 and can enter and accumulate in dopaminergic neurons, 12 the cells lost in PD.
(mh=_guMo12wjxzTRnEh)5.jpg "SEX AGENCY in Moreno Valley")
Furthermore, studies have demonstrated that paraquat can directly cause and exacerbate alpha-synuclein pathology 13β17 and lead to degeneration of dopaminergic neurons, 18 along with other toxic mechanisms.
