Background: The focus on remnant cholesterol RC has intensified because of its association with various diseases. In this study, we investigated the association between RC and depression in middle-aged and older adults. Methods: The study involved 7, participants from the and waves of the China Health and Retirement Longitudinal Study. To assess the correlation between RC levels and depression, a logistic regression model that incorporated restricted cubic spline techniques was used.
Results: Of the study population, mean age: From to , the mean CESD score increased from 6. Following adjustment for confounding factors, individuals in the higher RC level quartile exhibited a higher depression risk Q3: odds ratio [OR]: 1.
And the subgroup analysis yielded results consistent with the primary findings. Conclusion: This study revealed that in China, in middle-aged and older individuals, elevated RC levels were associated with a higher depression risk, suggesting RC is a promising target for depression prevention and treatment.
Depression, a prevalent mood disorder, has significant implications for the overall quality of life as well as potential disability- and mortality-associated outcomes 1 โ 3. In middle-aged and older adults, the propensity to overlook depression and leave it untreated is often attributed to a high comorbidity prevalence, which emphasizes the crucial need for enhanced depression prevention strategies.
Previous studies indicate that depression is associated with elevated total cholesterol TC 4 and triglycerides levels 5 , as well as reduced low-density lipoprotein cholesterol LDL-C 6 , high-density lipoprotein cholesterol HDL-C 5 , and omega-3 polyunsaturated fatty acids levels 7. However, other studies have reported no association between depression and LDL-C 4 , 8 or TC levels 8 , 9 , or found associations only in certain populations 6.
