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No use, distribution or reproduction is permitted which does not comply with these terms. Bisphenol A BPA , a plasticizer and endocrine disruptor, has been substituted by bisphenol S BPS , a structural analogue that had already shown adverse effects on granulosa cell steroidogenesis.
The objective of this study was to assess the effect of chronic exposure to BPS, a possible endocrine disruptor, on steroid hormones in the ovary, oviduct and plasma using the ewe as a model.
Given the interaction between steroidogenesis and the metabolic status, the BPS effect was tested according to two diet groups. Eighty adult ewes were allotted to restricted R and well-fed WF groups, that were further subdivided into two subgroups. A deleterious effect of restricted diet on the volume of oviduct fluid and numbers of pre-ovulatory follicles was observed. Exposure to BPS impaired estradiol concentrations in both follicular and oviduct fluids of well-fed ewes and progesterone, estradiol and estrone concentrations in plasma of restricted ewes.
In addition, a significant interaction between metabolic status and BPS exposure was observed for seven steroids, including estradiol. In conclusion, BPS acts in ewes as an endocrine disruptor with differential actions according to metabolic status. Bisphenol A BPA , a plasticizer, was reported as an endocrine disruptor that impairs both male and female reproductive function 1 β 3 , and has been banned in the food industry in several countries Canada, Belgium and France.
