Official websites use. Share sensitive information only on official, secure websites. Corresponding author. E-mail address: didier. The work cannot be changed in any way or used commercially without permission from the journal. Each treatment period consisted of 5 daily stimulation sessions and 2 follow-up visits at 1 and 3 weeks after the last stimulation session.
Secondary outcomes included neuropathic symptoms NPSI , pain interference, patient global impression of change PGIC , anxiety, depression, and catastrophizing. In total, 51 patients participated in at least one session of both treatments.
The effects of F8-coil stimulation appeared earlier, whereas the effects of H-coil stimulation were delayed, but tended to last longer up to 3 weeks as regards to several secondary outcomes PGIC and total NPSI score. Keywords: Neuromodulation, Brain stimulation, Analgesia, Central neuropathic pain, Randomized clinical trial. In recent years, repetitive transcranial magnetic stimulation rTMS has emerged as a promising noninvasive approach for the treatment of neuropathic pain NP.
Higher intensities would be required to stimulate deeper brain structures with these coils, but this could significantly increase the risk of adverse events. Technological innovations led to the development of deep rTMS as early as This allows larger brain areas to be stimulated, reaching structures located up to 4 to 5 cm beneath the surface of the skull. Deep rTMS is currently widely used in psychiatry for the treatment of various conditions and has FDA clearance for the treatment of major depression and certification for use in Europe for various psychiatric conditions, such as unipolar depression, bipolar depression, negative symptoms of schizophrenia, and post-traumatic stress disorders.
The primary outcome measure was average daily pain intensity. Secondary outcomes included pain interference, neuropathic pain symptoms, anxiety, depression, and catastrophizing. The study was approved by local ethics committee and registered in clinical trials. All participants provided written informed consent at inclusion, and the study conformed to the Declaration of Helsinki and Good Clinical Practice Guidelines. Inclusion took place 2 to 4 weeks before randomization. Patients were assessed for inclusion and exclusion criteria and underwent a brain MRI for the determination of the position of the F8-coil stimulation with neuronavigation.
